All settings are saved on the board so they will persist through power cycles. I believe that Cabinet Settings also persists through game changes, so once you set a cabinet type then it should persist as you change games.
Game-specific settings persist through power cycles but reset to defaults when you change games. Remember that when the STV was originally used in a commercial arcade environment, games wouldn’t be changed very often, so operators expect to go into the Service Menu when changing a game to set it up for the first time.