im not sure if this is outdated, but it looks like MagicGate is another hurdle.
here's some stuff to look at:
https://github.com/PCSX2/pcsx2/pull/4274
https://twitter.com/balika011/status/1369624516457078789
https://github.com/PCSX2/pcsx2/issues/3613
they say they'd need legal advice, so idk...